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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 348755생성일: 2026년 10월 25일

Sodium sulfate decahydrate → [2-(4-dipropylaminobutyl)-3-propyl-3H-benzimidazol-5-yl]methanol

https://huagongshe.com/reaction/348755

반응식

참여 물질

역할이름HCID투입량
반응물Sodium sulfate decahydrateHCID 62649—
반응물Aluminium lithium hydrideHCID 21226445—
반응물2-(4-dipropylaminobutyl)-3-propyl-3H-benzimidazole-5-carboxylic Acid Methyl EsterHCID 66941829—
용매TetrahydrofuranHCID 8028—
생성물[2-(4-dipropylaminobutyl)-3-propyl-3H-benzimidazol-5-yl]methanolHCID 2307922190.4%

반응 조건

온도0 °C

반응 단계

Lithium aluminum hydride (138 mg) was suspended in THF (7 ml) and then cooled to 0° C. After that, a solution of the compound (361 mg) obtained in Example 125-3 in THF (7 ml) was dropped in the suspension, followed by stirring at 0° C. for 1 hour. After completion of the reaction, sodium sulfate decahydrate was continuously added to the solution until bubbling was stopped, and a 1 mol/l sodium hydroxide aqueous solution was then added to the mixture until a white precipitate was generated. Solid matter was separated through filtration and the solvent was then distilled off from the filtrate under reduced pressure. The residue was dried under vacuum, thereby obtaining the subject compound (302 mg) as a pale-yellow viscous substance.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07176227B2
출처 데이터셋uspto-grants-2007_02
ORD IDord-b756104c07a7402997aa5cdc1539678c
출처 메모uspto-grants-2007_02