Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 348755생성일: 2026년 10월 25일
Sodium sulfate decahydrate → [2-(4-dipropylaminobutyl)-3-propyl-3H-benzimidazol-5-yl]methanol
https://huagongshe.com/reaction/348755
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium sulfate decahydrate | HCID 62649 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 반응물 | 2-(4-dipropylaminobutyl)-3-propyl-3H-benzimidazole-5-carboxylic Acid Methyl Ester | HCID 66941829 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | [2-(4-dipropylaminobutyl)-3-propyl-3H-benzimidazol-5-yl]methanol | HCID 23079221 | 90.4% |
반응 단계
Lithium aluminum hydride (138 mg) was suspended in THF (7 ml) and then cooled to 0° C. After that, a solution of the compound (361 mg) obtained in Example 125-3 in THF (7 ml) was dropped in the suspension, followed by stirring at 0° C. for 1 hour. After completion of the reaction, sodium sulfate decahydrate was continuously added to the solution until bubbling was stopped, and a 1 mol/l sodium hydroxide aqueous solution was then added to the mixture until a white precipitate was generated. Solid matter was separated through filtration and the solvent was then distilled off from the filtrate under reduced pressure. The residue was dried under vacuum, thereby obtaining the subject compound (302 mg) as a pale-yellow viscous substance.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07176227B2 |
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| 출처 데이터셋 | uspto-grants-2007_02 |
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| ORD ID | ord-b756104c07a7402997aa5cdc1539678c |
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| 출처 메모 | uspto-grants-2007_02 |
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