Tetrahydrofuran → HCID 23079270, compound

Participants

Reaction Steps

The compound (2.03 g) obtained in Example 127-4 was dissolved in methanol (60.9 ml) and THF (30.5 ml) and, under ice-cooling, added with sodium borohydride (0.442 g), followed by stirring at room temperature for 2 hours. The reaction solution was added with a saturated aqueous ammonium chloride solution and then subjected to separation/extraction with chloroform. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (hexane/ethyl acetate), thereby obtaining the subject compound (1.54 g) as a yellow oily substance.

Provenance & Evidence