Hydrochloric Acid → N2-[(2R,3S)-3-Amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]-N1-isobutyl-L-alaninamide dihydrochloride

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Reaction Steps

[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(1-isobutylcarbamoyl-ethylamino)-propyl]-carbamic acid tert-butyl ester (2.7 g, 6 mmol) is dissolved in excess 4N hydrochloric acid in dioxane, and the reaction is stirred 2 h at room temperature. The solution is concentrated under reduced pressure to give the title compound. ESI MS m/z 344.3 [M+H]+.

Provenance & Evidence