Water → 3-{[(tert-Butoxycarbonyl)(butyl)amino]methyl}-5-methylbenzoic Acid

Participants

Reaction Steps

To a stirred solution of methyl 3-{[(tert-butoxycarbonyl)(butyl)amino]methyl}-5-methylbenzoate (70 mg, 0.21 mmol) in methanol (2 mL), tetrahydrofuran (1 mL), and water (1 mL) is added lithium hydroxide (88 mg, 2.1 mmol), and the reaction mixture stirred at room temperature for 2 h. The reaction mixture is concentrated under reduced pressure, dissolved in methylene chloride, filtered, and the filtrate concentrated under reduced pressure to provide the title compound.

Provenance & Evidence