反应详情

To a stirred solution of methyl 4-butyl-1-(methylsulfonyl)-1,2,3,4-tetrahydroquinoxaline-6-carboxylate (144 mg) in methanol (1.3 mL) was added 1 M potassium hydroxide (13 mL). The mixture was stirred at room temperature for 48 h and concentrated under reduced pressure. The residue was diluted with water and washed with ethyl acetate. The aqueous layer was acidified to pH 4 with 1 N hydrochloric acid and extracted with chlorform (4×100 mL). The combined organic extracts were dried (sodium sulfate), filtered, and concentrated under reduced pressure to give 99 mg of the title compound: 1NMR (300 MHz, CDCl3) δ 7.43, 7.39, 7.24, 3.77, 3.39, 3.32, 1.56, 1.33, 0.90.

1. concentrationconcentrated under reduced pressure
2. additionThe residue was diluted with water
3. washwashed with ethyl acetate
4. extractionextracted with chlorform (4×100 mL)
5. dry with materialThe combined organic extracts were dried (sodium sulfate)
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure