HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl quinoline-7-carboxylate → Methyl 1,2,3,4-tetrahydroquinoline-7-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl quinoline-7-carboxylate | HCID 12554532 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 1,2,3,4-tetrahydroquinoline-7-carboxylate | HCID 16244389 | 98.8% |
Reaction Steps
A solution of methyl quinoline-7-carboxylate (185 mg, 1.0 mmol) and PtO2 (20 mg) in methanol (10 mL) was shaken under an atmosphere of hydrogen for 2 h. The reaction mixture was filtered through diatomaceous earth, and concentrated under reduced pressure to provide methyl 1,2,3,4-tetrahydroquinoline-7-carboxylate (189 mg): ESI MS m/z 192 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176242B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-02acc3f835484419afed0281129fcee5 |
| Source note | uspto-grants-2007_02 |