2-(3-Oxocyclohexyl)acetic acid → N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxocyclohexyl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-(3-Oxocyclohexyl)acetic acid	HCID 3726815	—
Reactant	N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxo-4-propylcyclohexyl)acetamide	HCID 57512052	—
Product	N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxocyclohexyl)acetamide	HCID 57512632	23%

Reaction Steps

Step 3 N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxocyclohexyl)acetamide was prepared in 23% yield from (3-Oxo-cyclohexyl)-acetic acid by the method described for the synthesis of N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxo-4-propylcyclohexyl)acetamide (EXAMPLE SP-297.)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07176242B2
Source dataset	uspto-grants-2007_02
ORD ID	ord-d64542484f4e4906b4ffb0e579f9ac83
Source note	uspto-grants-2007_02