Acetophenone → 1-Phenylethanol, (S)-

HRID 349155Notes

Reaction equation

HRID 349155 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2]>O>[C:4]1([C@@H:1]([OH:3])[CH3:2])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 7410Acetophenone

Product 1

HCID 4431351-Phenylethanol, (S)-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Washed phaseolus aureus L (green grams) 500 g. were taken into a conical flask and allowed to soak in deionised water (4 L) for a period of 24 hr. Acetophenone (5 g; 0.0416 moles) I(a) was added to the soaked phaseolus aureus L (green grams) in the above water, covered and allowed to shake for 24 hr at room temperature (28° C). Then the green grams were filtered off and washed with deionised water (5×600 ml). The combined filtrate was extracted with chloroform (30×500 ml). The chloroform layer was dried and the crude product obtained (3.21 g.). Pure 1-phenyl-(1S)-ethan-1-ol II(a) was obtained after column chromatography with silica gel using chloroform as eluent.

Workup

  1. washWashed phaseolus aureus L (green grams) 500 g
  2. customwere taken into a conical flask
  3. waitto shake for 24 hr at room temperature
  4. custom(28° C)
  5. filtrationThen the green grams were filtered off
  6. washwashed with deionised water (5×600 ml)
  7. extractionThe combined filtrate was extracted with chloroform (30×500 ml)
  8. dry with materialThe chloroform layer was dried
  9. customthe crude product obtained (3.21 g.)

Sources & evidence

ORD record
ord-377464c3c84c41e9bb18ba351f1954bf
Source dataset
uspto-grants-2007_02
Patent number
US07179624B2

Reaction notes

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