N-methyl-2-pyrrolidone → HCID 69433518, compound

Participants

Reaction Conditions

Reaction Steps

A solution of sodium methoxide in methanol (5.0M, 10 ml) I s added to a solution of 2-(3-pentylamino)-6-chloropyrazine (3.3 g, 16.5 mmol) in 1-methyl-2-pyrrolidinone (15 mL) at room temperature. The resulting solution is heated to 50° C. for 20 hours then evaporated and poured into water and extracted twice with ethyl acetate/hexane (1:1). Combined extracts are dried (sodium sulfate), filtered, concentrated, and chromatographed to give N-(1-ethyl)propyl-6-methoxypyrazine-2-amine as a light yellow solid (98%).

Provenance & Evidence