HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Ethyl-6-methoxy-5-[2-methoxy4-(trifluoromethoxy)phenyl]pyrazin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | {3-Ethyl-6-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]pyrazin-2-yl} [(4-methoxyphenyl)methyl]amine | HCID 22248943 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-Ethyl-6-methoxy-5-[2-methoxy4-(trifluoromethoxy)phenyl]pyrazin-2-ylamine | HCID 22248898 | 93.2% |
Reaction Steps
1M hydrochloric acid in ether (2 mL) and 10% palladium on carbon (40 mg) are added to {3-ethyl-6-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]pyrazin-2-yl}[(4-methoxyphenyl)methyl]amine (115 mg, 0.25 mmol) in methanol (3 mL) under a nitrogen atmosphere. The mixture is then hydrogenated at 1 ATM for 18 hours, filtered through Celite and evaporated to give 3-ethyl-6-methoxy-5-[2-methoxy-4(trifluoromethoxy)phenyl]pyrazin-2-ylamine (80 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07179807B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-1833e10179654bc8b528b4344393e123 |
| Source note | uspto-grants-2007_02 |