N-Methylethylenediamine → HCID 11676043, compound

HRID 349200Notes

Reaction equation

HRID 349200 reaction equation
C(OC([NH:8][C@@H:9](C)[CH2:10][NH:11][C:12]1[N:13]([CH2:35][C:36]#[C:37][CH3:38])[C:14]2[C:19](=[O:20])[N:18]([CH2:21][C:22]3[N:23]=CC4C(C=3C#N)=CC=CC=4)[N:17]=[CH:16][C:15]=2[N:34]=1)=O)(C)(C)C.BrC1N(CC#CC)C2C(=O)N(CC3C4[C:54](=[CH:55][CH:56]=CC=4)[CH:53]=[C:52]([CH3:60])N=3)C=CC=2N=1.Cl[C:68]1N(CC#CC)C2C(=O)N(CC3C4C(=CC=CC=4)C=C(C)N=3)C=CC=2N=1.CN[CH2:96][CH2:97][NH2:98]>>[NH2:8][CH2:9][CH2:10][N:11]([C:12]1[N:13]([CH2:35][C:36]#[C:37][CH3:38])[C:14]2[C:19](=[O:20])[N:18]([CH2:21][C:22]3[N:23]=[C:55]([CH3:56])[C:54]4[C:97](=[CH:96][CH:60]=[CH:52][CH:53]=4)[N:98]=3)[N:17]=[CH:16][C:15]=2[N:34]=1)[CH3:68]

Participants

5

Reactant 4

HCID 8014N-MethylethylenediamineHCID 68973069HCID 68973069, compoundHCID 68973094HCID 68973094, compoundHCID 68975714HCID 68975714, compound

Product 1

HCID 11676043HCID 11676043, compound

Procedure

Product (2) was obtained by reacting a 1:1 mixture of 2-bromo-3-(2-butyn-1-yl)-5-[(3-methyl-isoquinolin-1-yl)methyl]-3,5-dihydro-imidazo[4,5-c]pyridin-4-one and 2-chloro-3-(2-butyn-1-yl)-5-[(3-methyl-isoquinolin-1-yl)methyl]-3,5-dihydro-imidazo[4,5-c]pyridin-4-one with N-methyl-ethylenediamine according to the instructions described above.

Sources & evidence

ORD record
ord-18ed3938380a4c8a9e3bda1f6c8805db
Source dataset
uspto-grants-2007_02
Patent number
US07179809B2

Reaction notes

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