5-Bromo-2-(4-[1,2,3]triazol-1-yl-but-1-ynyl)-pyrimidine → 5-Bromo-2-(4-[1,2,3]triazol-1-yl-butyl)-pyrimidine

Participants

Reaction Steps

5-Bromo-2-(4-[1,2,3]triazol-1-yl-but-1-ynyl)-pyrimidine (0.350 g, 1.26 mmol) is dissolved in ethyl acetate (3 ml) and hydrogenated for 2 h at r.t. in the presence of palladium on charcoal (10%, 175 mg). The reaction mixture is filtered and concentrated in vacuo to yield 5-Bromo-2-(4-[1,2,3]triazol-1-yl-butyl)-pyrimidine as a beige solid. Yield 290 mg (82%)

Provenance & Evidence