2-Morpholinoethylamine → HCID 21087771, compound

Participants

Reaction Steps

Add 4-(2-aminoethyl)-morpholine (129 mg, 0.992 mmol) to a solution of 4-[1-(3,5-bis-trifluoromethyl-benzyl)-5-phenyl-1H-[1,2,3]triazole-4-carbonyl]-3-(2-chloro-phenyl)-isoxazole-5-carbaldehyde (150 mg, 0.248 mmol) in 1,2-dichloroethane (2.5 mL). Then add NaBH(OAc)3 (157 mg, 0.744 mmol) and allow the mixture to stir at RT. After 3 h., quench the reaction with water and extract with EtOAc (2×50 mL). Dry the organic layer over MgSO4, filter, and concentrate in vacuo. Purify the residue by flash chromatography on silica gel to provide the title compound (61% yield) as a brown oil. MS (ES) 720.1 (M++1); TLC Rf=0.1 (EtOAc).

Provenance & Evidence