Hydrochloric Acid → HCID 136368227, compound

Participants

Reaction Steps

To a solution of 4-[1-(3,5-Bis-trifluoromethyl-benzyl)-5-phenyl-1H-[1,2,3]triazole-4-carbonyl]-5-(2-chloro-phenyl)-isoxazole-3-carbaldehyde (0.076 g, 0.13 mmol) in CH2Cl2 (2 mL) and MeOH (2 mL), add sodium acetate trihydrate (0.034 g, 0.25 mmol) and hydroxylamine.HCl (0.018 g, 0.25 mmol) and stir at RT. After 1 h., quench with 75% sat. aq. NH4Cl (4 mL), extract with ethyl acetate, and wash with brine. Dry over MgSO4, filter and concentrate under vacuum. Purify by flash chromatography, (EtOAc/Hexane 10%–50%) to give the title compound. MS(ES) 620.1 (M+1), 1H NMR (300 MHz, CDCl3) δ 8.34 (s, 1H), 7.83 (br s, 2H), 7.74–7.16 (m, 9H), 5.50 (s, 2H).

Provenance & Evidence