Dichloromethane → N-(2-aminoethyl)-4-nitropyridine-2-carboxamide hydrochloride

Participants

Reaction Steps

7.0 g of t-butyl [2-(4-nitropyridine-2-carboxamido)ethyl]carbamate were stirred at room temperature with 9 ml of methylene chloride and 9 ml of trifluoroacetic acid. Thereafter, the reaction mixture was concentrated under reduced pressure. The residue was converted with hydrogen chloride in ethanol into the hydrochloride and this was recrystallized from ethanol/ether. There was obtained N-(2-aminoethyl)-4-nitropyridine-2-carboxamide hydrochloride as white crystals, m.p. 193°-194°.

Provenance & Evidence