HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(2-aminoethyl)-3-phenoxypyridine-2-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | t-Butyl [2-(3-phenoxypyridine-2-carboxamido)ethyl]carbamate | HCID 13800228 | — |
| Product | N-(2-aminoethyl)-3-phenoxypyridine-2-carboxamide hydrochloride | HCID 13800260 | — |
Reaction Steps
8.7 g of t-butyl [2-(3-phenoxypyridine-2-carboxamido)ethyl]carbamate were reacted with trifluoroacetic acid in an analogous manner to that described in Example 3, paragraph 2. The residue was converted into the hydrochloride which was recrystallized twice from ethanol/ether, whereby there was obtained N-(2-aminoethyl)-3-phenoxypyridine-2-carboxamide hydrochloride as white crystals, m.p. 180°-186°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764522 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-64f995007abf4ea6972aba508349a44e |
| Source note | uspto-grants-1988_08 |