Hydrochloric Acid → N-(2-aminoethyl)-3-methyl-4-nitropyridine-2-carboxamide hydrochloride

Participants

Reaction Steps

14.6 g of t-butyl [2-(3-methyl-4-nitropyridine-2-carboxamido)ethyl]carbamate were reacted with trifluoroacetic acid in an analogous manner to that described in Example 2, paragraph 2. The residue was converted into the hydrochloride which was recrystallized from methanol/ether, whereby there was obtained N-(2-aminoethyl)-3-methyl-4-nitropyridine-2-carboxamide hydrochloride as white crystals, m.p. 204°-205°.

Provenance & Evidence