Ethyl acetate hexane → HCID 21297365, compound

HRID 34941Notes

Reaction equation

HRID 34941 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][N:5]=[C:4]([C:10](NCCNC(=O)OC(C)(C)C)=[O:11])[CH:3]=1.C(OCC)(=[O:25])C.CCCCCC>>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][N:5]=[C:4]([C:10]([OH:11])=[O:25])[CH:3]=1

Participants

3

Reactant 2

HCID 21226206Ethyl acetate hexaneHCID 53859955HCID 53859955, compound

Product 1

HCID 21297365HCID 21297365, compound

Procedure

In analogous manner, from 3.3 g of 4-chloro-5-methoxy-2-pyridinecarboxylic acid there was obtained t-butyl [2-(4-chloro-5-methoxypyridine-2-carboxamido)ethyl]carbamate as pale yellow crystals (ethyl acetate/n-hexane), m.p. 132°-133°, which, in turn, was converted into N-(2-aminoethyl)-4-chloro-5-methoxypyridine-2-carboxamide hydrochloride, white crystals (methanol/ether), m.p. 256°-257°.

Sources & evidence

ORD record
ord-eea740e3ab3346a6ac17cb129455a0fb
Source dataset
uspto-grants-1988_08
Patent number
US04764522

Reaction notes

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