反应详情

0.55 g of 3,4-diaminothiophene dihydrobromide was added to a solution of 0.51 g of N-ethyl-N,N-diisopropylamine in 30 ml of anhydrous THF, the mixture was stirred at room temperature for approx. 5 minutes and the solution was then admixed with a mixture of 0.4 g of 2-chloro-4-methyl-3-thienyl isothiocyanate in 5 ml of THF. The mixture was stirred at room temperature for 3 hours and at 40° C. for 10 minutes. After it had been left to stand overnight, the solvent was distilled off, and the residue was treated with water and extracted with ethyl acetate. The insoluble fraction was filtered off, and the organic phase was washed with water and dried over sodium sulfate. After the solvent had been distilled off, the product was purified by column chromatography on silica gel using a mixture of 1 part by volume of toluene and 1 part by volume of ethyl acetate and, after the solvent had been distilled off, the N-(4-amino-3-thienyl)-N′-(2-chloro-4-methylthienyl)thiourea was obtained as a crystalline solid.

1. stirringThe mixture was stirred at room temperature for 3 hours and at 40° C. for 10 minutes
2. waitAfter it had been left
3. waitto stand overnight
4. distillationthe solvent was distilled off
5. additionthe residue was treated with water
6. extractionextracted with ethyl acetate
7. filtrationThe insoluble fraction was filtered off
8. washthe organic phase was washed with water
9. dry with materialdried over sodium sulfate
10. distillationAfter the solvent had been distilled off
11. customthe product was purified by column chromatography on silica gel using
12. additiona mixture of 1 part by volume of toluene and 1 part by volume of ethyl acetate
13. distillationafter the solvent had been distilled off