Trifluoroacetic acid → 4-{[5-(3-Iodophenyl)-2H-tetrazol-2-yl]methyl}benzoic acid

Participants

Reaction Conditions

Reaction Steps

The ester (2.5 g, 5.41 mmol) prepared in Step (b) was suspended in dichloromethane (20 mL) followed by the addition of trifluoroacetic acid (5 mL). The solution was stirred for 16 hours at 25° C., then concentrated in vacuo. The resulting white solid was triturated with hexane/diethyl ether and the carboxylic acid (2.1 g, 100%) was collected by filtration. Mp 241–242° C.

Provenance & Evidence