Trimethylsilyl iodide → HCID 86626607, compound

Participants

Reaction Steps

A solution of [4-(5-{3-[3-(4-fluorophenyl)prop-1-ynyl]phenyl}tetrazol-2-ylmethyl)benzyl] phosphonic acid dimethyl ester (0.25 g, 0.53 mmol) in methylene chloride (15 mL) was cooled to 0° C., then treated with trimethylsilyliodide (0.23 mL, 1.33 mmol). The reaction mixture was removed from the cooling bath and stirred at room temperature for 1 hour. The reaction mixture was concentrated on the rotary evaporator without heat and the residue was treated with chloroform. The resulting solid was collected by filtration, washed with chloroform, triturated with hot ether, collected by filtration and dried. High performance liquid chromatography (“HPLC”) indicates that this solid is 65% pure.

Provenance & Evidence