HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(2-aminoethyl)-5-methylthiophene-2-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | t-Butyl [2-(5-methylthiophene-2-carboxamido)ethyl]carbamate | HCID 13800237 | — |
| Product | N-(2-aminoethyl)-5-methylthiophene-2-carboxamide hydrochloride | HCID 13800278 | — |
Reaction Steps
14.9 g of t-butyl [2-(5-methylthiophene-2-carboxamido)ethyl]carbamate were reacted with trifluoroacetic acid in an analogous manner to that described in Example 2, paragraph 2. The residue was converted into the hydrochloride which was recrystallized from ethanol/ether, whereby there was obtained N-(2-aminoethyl)-5-methylthiophene-2-carboxamide hydrochloride as light beige crystals, m.p. 161°-162°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764522 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-101794b9408f47a58dcd4619b62278d9 |
| Source note | uspto-grants-1988_08 |