反应详情

3-[(4-nitro-benzimidoyl)-amino]-4-methoxy-benzoic acid methyl ester (1.63 g, 4.95 mmol) was dissolved in 50% methanol, and 5% NaOCl was added dropwise thereto at room temperature. After checking the reaction by TLC, Na2CO3 (1.05 g, 9.38 mmol) seas added dropwise thereto and refluxed for 40 min. The resulting solution was cooled to room temperature, extracted with ethyl acetate and the extract was concentrated under a reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain the title compound (0.75 g, 2.28 mmol) in a yield of 46%.

1. customat room temperature
2. additionadded dropwise
3. temperaturerefluxed for 40 min
4. extractionextracted with ethyl acetate
5. concentrationthe extract was concentrated under a reduced pressure
6. customThe resulting residue was purified by silica gel column chromatography