Water → HCID 17962012, compound

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (3.01 g) in tetrahydrofuran (150 ml) was added 1-ethyl-5-(tritylamino)-1H-pyrazole-4-carbonitrile (7.5 g) at room temperature. The mixture was refluxed for 55 hours. After cooling on an ice bath, sodium fluoride (13.3 g) and water (6 ml) were added to the reaction mixture. The insoluble materials were removed by filtration. The filtrate was evaporated to give 4-aminomethyl-1-ethyl-5-tritylaminopyrazole (3.4 g).

Provenance & Evidence