反应详情

A solution of ethyl 3-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)propionate (30 g) in saturated methanolic ammonia solution (700 ml) was stirred at 110° C. for 5 days in an autoclave. After evaporation of the solvent in vacuo, methylene chloride was added to the residue. The resulting solid was collected by filtration and dissolved in methanol. To the solution was added activated charcoal, and the mixture was filtered. The filtrate was concentrated in vacuo. The residue was triturated with acetonitrile and dried in vacuo to give 3-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)propionamide (11.3 g) as a solid.

1. customAfter evaporation of the solvent in vacuo, methylene chloride
2. additionwas added to the residue
3. filtrationThe resulting solid was collected by filtration
4. dissolutiondissolved in methanol
5. additionTo the solution was added
6. filtrationthe mixture was filtered
7. concentrationThe filtrate was concentrated in vacuo
8. customThe residue was triturated with acetonitrile
9. customdried in vacuo