Water → HCID 86760410, compound

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (1.8 g) in tetrahydrofuran (200 ml) was added 3-(1-trityl-2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)propanamide (10 g) at room temperature. The mixture was stirred at room temperature for 2.5 hours. After cooling on an ice bath, sodium fluoride (7.95 g) and water (3.4 ml) were added to the reaction mixture. The insoluble materials were removed by filtration. To the filtrate was added ethyl formate, and the mixture was refluxed for 24 hours. After evaporation of the solvent in vacuo, the residue was triturated with diisopropyl ether and dried in vacuo to give 3-(1-trityl-2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)propylformamide (6.62 g).

Provenance & Evidence