Water → HCID 17962014, compound

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (3.73 g) in tetrahydrofuran (100 ml) was added 2-[4-cyano-5-(tritylamino)-1H-pyrazol-1-yl]acetamide (5 g) at room temperature. The mixture was refluxed for 23 hours. After cooling on an ice bath, sodium fluoride (16.5 g) and water (7.1 ml) were added to the reaction mixture. The insoluble materials were removed by filtration. The filtrate was evaporated in vacuo and triturated with diisopropyl ether to give 1-(2-aminoethyl)-4-(aminomethyl)-5-tritylaminopyrazole (2.17 g).

Provenance & Evidence