Boron tribromide → HCID 21920934, compound

HRID 349590Notes

Reaction equation

HRID 349590 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([NH:8][CH:9]2[CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:18]C)[CH:15]=3)[CH2:10]2)=[O:7])=[CH:4][CH:3]=1.B(Br)(Br)Br.ClCCl.CO>ClCCl>[F:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([NH:8][CH:9]2[CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:18])[CH:15]=3)[CH2:10]2)=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 25134Boron tribromideHCID 21226129Dichloromethane methanolHCID 21921012HCID 21921012, compound

Product 1

HCID 21920934HCID 21920934, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.45 g (5.08 mmol) 4-fluoro-N-(5-methoxy-indan-2-yl)-benzamide were dissolved in 50 ml of dichloromethane, 13 ml (12.7 mmol) boron tribromide (1M in dichloromethane) were added, the whole was stirred for 30 min at RT. The resulting mixture was poured onto 200 ml of ice water, the organic phase was washed twice with water, dried, evaporated and the residue obtained was subjected to chromatography on silica with a mixture of dichloromethane/methanol 98:2.

Workup

  1. washthe organic phase was washed twice with water
  2. customdried
  3. customevaporated
  4. customthe residue obtained

Sources & evidence

ORD record
ord-46e9ad7e10ba401b9a77e816edf490f7
Source dataset
uspto-grants-2007_02
Patent number
US07179839B2

Reaction notes

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