[4-N-(2-methylthioethoxycarbonyl)-cytosin-1-yl]-acetic acid → N-[2-(Benzothiazole-2-sulfonylamino)-ethyl]-N-{[4-N-(2-methylthioethoxycarbonyl)-cytosin-1-yl]-acetyl}-glycine ethyl ester

Participants

Reaction Steps

The title compound (2.60 g, 85%) was synthesized by the reaction of N-[2-(benzothiazole-2-sulfonylamino)-ethyl]-glycine ethyl ester (1.72 g, 5 mmol) and [4-N-(2-methylthioethoxycarbonyl)-cytosin-1-yl]-acetic acid (1.44 g, 5 mmol) as per the procedure of Example 20. 1H NMR (500 MHz; DMSO-d6) δ 8.89 (t, 0.6H), 8.75 (t, 0.4H), 8.28 (dd, 1H), 8.19 (dd, 1H), 7.90 (d, 0.6H), 7.84 (d, 0.4H), 7.67 (m, 2H), 6.99 (m, 1H), 4.81 (s, 1.2H), 4.62 (s, 0.8H), 4.35 (s, 0.8H), 4.26 (t, 2H), 4.14 (q, 0.8H), 4.06 (s, 1.2H), 4.04 (q, 1.2H), 3.59 (t, 1.2H), 3.42 (m, 2.0H), 3.21 (q, 0.8H), 2.73 (t, 2H), 2.12 (s, 3H), 1.20 (t, 1.2H), 1.15 (t, 1.8H).

Provenance & Evidence