Ethyl N-{2-[(1,3-benzothiazole-2-sulfonyl)amino]ethyl}glycinate → HCID 136388990, compound

HRID 349633Notes

Reaction equation

HRID 349633 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][NH:6][CH2:7][CH2:8][NH:9][S:10]([C:13]1[S:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1)(=[O:12])=[O:11])[CH3:2].[CH3:23][S:24][CH2:25][CH2:26][O:27][C:28]([NH:30][C:31]1[NH:32][C:33](=[O:44])[C:34]2[N:35]=[CH:36][N:37]([CH2:40][C:41](O)=[O:42])[C:38]=2[N:39]=1)=[O:29]>>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][N:6]([CH2:7][CH2:8][NH:9][S:10]([C:13]1[S:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1)(=[O:12])=[O:11])[C:41](=[O:42])[CH2:40][N:37]1[CH:36]=[N:35][C:34]2[C:33](=[O:44])[NH:32][C:31]([NH:30][C:28]([O:27][CH2:26][CH2:25][S:24][CH3:23])=[O:29])=[N:39][C:38]1=2)[CH3:2]

Participants

3

Reactant 2

HCID 21868443Ethyl N-{2-[(1,3-benzothiazole-2-sulfonyl)amino]ethyl}glycinateHCID 135616177HCID 135616177, compound

Product 1

HCID 136388990HCID 136388990, compoundYield 81.8%

Procedure

The title compound (2.67 g, 75%) was synthesized by the reaction of N-[2-(benzothiazole-2-sulfonylamino)-ethyl]-glycine ethyl ester (1.72 g, 5 mmol) and [2-N-(2-methylthioethoxycarbonyl)-guanin-9-yl]-acetic acid (1.64 g, 5 mmol) as per the procedure of Example 20.

Sources & evidence

ORD record
ord-0c690917627d43b19e6850aa0c18b9a2
Source dataset
uspto-grants-2007_02
Patent number
US07179896B2

Reaction notes

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