反应详情

A solution of 2-(tert-butyl-dimethyl-silanyloxy)-5-Nitro-benzoic acid methyl ester (4.9 g, 16 mmol) in ethanol (100 mL) was treated with hydrogen gas (60 psi) for 48 h in the presence of palladium on carbon catalyst (0.31 g, 10% Pd). The catalyst was removed by filtration through CELITE®, and the filtrate was concentrated to a syrup and dried in vacuo to afford the intermediate 5-amino-2-(tert-butyl-dimethyl-silanyloxy)-benzoic acid methyl ester as a dark brown solid (4.52 g, 99%).

1. customThe catalyst was removed by filtration through CELITE®
2. concentrationthe filtrate was concentrated to a syrup
3. customdried in vacuo