反应详情

A solution of 4-methylsalicylic acid (75 g, 0.49 mmol) in MeOH (500 mL) at 0° C. was treated with dicyclohexylcarbodiimide (101 g, 0.49 mmol) and the mixture was stirred at room temperature for 2 h. The precipitated dicyclohexylurea was removed by filtration and the filtrate was concentrated in vacuo. The crude residue was purified by distillation (110° C. bath temp, 0.5 mm Hg) to afford 4-methylsalicylic acid methyl ester

1. customThe precipitated dicyclohexylurea was removed by filtration
2. concentrationthe filtrate was concentrated in vacuo
3. distillationThe crude residue was purified by distillation (110° C. bath temp, 0.5 mm Hg)