Hydrochloric Acid → HCID 69296468, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-hydroxy-4-morpholin-4-ylmethyl-benzoic acid methyl ester hydrochloride (75 mg, 0.26 mmol) in MeOH (0.5 mL) was treated with ammonium hydroxide (1 mL) and stirred in a sealed vial for 2 h at 60° C. After cooling, the reaction mixture was concentrated under a stream of nitrogen to approximately ¼ the original volume and was treated with 1 M HCl (0.25 mL, 0.25 mmol). The solid that formed was collected by filtration and recrystallized from water to yield the white crystalline product.

Provenance & Evidence