HCID 86602761, compound → HCID 86602760, compound

Participants

Reaction Steps

A flask was charged with (S)-(1-(3,5-bis(trifluoromethyl)benzyloxy)-4-nitro-2-phenylbut-3-en-2-yloxy)triethylsilane (35 mg, 64 μmol), methanol (1.5 mL), and platinum dioxide (20 mg, 88 μmol). The flask was purged with hydrogen and stirred under a balloon of hydrogen for 2 h. The reaction was filtered through celite and concentrated. Column chromatography (5% methanol/dichloromethane) gave 20 mg (60%) as a colorless oil. Retention time: 1.98 min. (Phenomenex C18 3.0×50 mm, 10% MeOH/90% H2O/0.1% TFA→90% MeOH/10% H2O/0.1% TFA, Gradient time=2 min., Flow rate=5 mL/min.) Mass spec.: 522.16 (MH)+.

Provenance & Evidence