HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 5-Methanesulfonyl-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 5-(methylsulfonyl)-1H-indole-2-carboxylate | HCID 735868 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Methanesulfonyl-1H-indole-2-carboxylic acid | HCID 22394446 | 23.8% |
Reaction Steps
To a solution of the 5-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester (0.49 g) in THF (12 mL) and water (4 ml) was added LiOH (0.098 g). The reaction mixture was left to stir for 2 hours. Acetic acid was added and the product extracted with dichloromethane. The organic extracts were combined, dried with magnesium sulfate, filtered and the filtrate evaporated to give the title compound as a solid (0.110 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07179922B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-59bd6241b13b4cf58ff933b7a25a70c8 |
| Source note | uspto-grants-2007_02 |