反应详情

A solution of ethyl 2-(8-chloro-6-cyano-2,3-dihydro-5-oxopyrrolo[1,2,3-de]-1,4-benzoxazine-6-yl)-2-cyanoacetate (1 g) in sulfuric acid (0.5 ml)-acetic acid (10 ml) was heated under reflux for 2 hours. The reaction mixture was poured into ice water, and the resulting precipitate was collected by filtration. Recrystallization from acetic acid afforded colorless crystals (0.48 g, 57%), mp 271° C.

1. temperatureunder reflux for 2 hours
2. filtrationthe resulting precipitate was collected by filtration
3. customRecrystallization from acetic acid afforded colorless crystals (0.48 g, 57%), mp 271° C.