反应详情

温度

75 °C

A 20 L jacketed reactor was fitted with a reflux condenser and a nitrogen inlet. To the flask was charged 1006 g (8.81 mol) of (E)-2-methyl-2-pentenoic acid, 1250 g (7.661 mol) of (S)-(+)-4-phenyl-oxazolidin-2-one, 2179 g (8.81 mol) of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline (EEDQ), 81 g (1.915 mol) of lithium chloride, and 12.5 L of ethyl acetate (EtOAc). The reaction was heated to 75° C. for 20 hours and then cooled to room temperature. The reaction solution was extracted 3× with 4 L aliquots of 1N HCl and 1× with 4 L of 0.2N NaOH. The 20 L reactor was fitted with a distillation head. The organic layer was distilled to remove, in succession: 6.5 L of EtOAc, after which 8 L of heptane was added back to the reactor; 4 L of EtOAc/heptane, after which 4 L of heptane was added to the reactor; and 4 L of EtOAc/heptane, after which 8 L of heptane was added to the reactor. After an additional 2 L of EtOAc/heptane was removed by distillation, the reaction mixture was cooled to an internal temperature of 40° C., and the reactor contents were charged to a filter and filtered under 5 psig of nitrogen washing with 8 L of heptane. The solids were dried under 5 psig of nitrogen overnight to give 1772 g of the titled compound: 1H-NMR (DMSO) 7.363–7.243 (m, 5H), 6.137–6.096 (m, 1H), 5.434–5.394 (m, 1H), 4.721–4.678 (t, 1H, J=8.578), 4.109–4.069 (m, 1H), 2.119–2.044 (m, 2H), 1.703–1.700 (d, 3H, J=1.364), 0.945–0.907 (t, 3H, J=7.603); Anal Calc'd for C15H17N1O3: C, 69.48; H, 6.61; N, 5.40. Found: C, 68.66; H, 6.60; N, 5.60. MS (Ion Mode: APCl) m/z=260 [M+1]+.

1. customwas fitted with a reflux condenser and a nitrogen inlet
2. temperaturecooled to room temperature
3. extractionThe reaction solution was extracted 3× with 4 L aliquots of 1N HCl and 1× with 4 L of 0.2N NaOH
4. customThe 20 L reactor was fitted with a distillation head
5. distillationThe organic layer was distilled
6. customto remove, in succession
7. addition6.5 L of EtOAc, after which 8 L of heptane was added back to the reactor
8. addition4 L of EtOAc/heptane, after which 4 L of heptane was added to the reactor
9. additionand 4 L of EtOAc/heptane, after which 8 L of heptane was added to the reactor
10. customAfter an additional 2 L of EtOAc/heptane was removed by distillation
11. temperaturethe reaction mixture was cooled to an internal temperature of 40° C.
12. additionthe reactor contents were charged to
13. filtrationa filter
14. filtrationfiltered under 5 psig of nitrogen washing with 8 L of heptane
15. customThe solids were dried under 5 psig of nitrogen overnight