HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Codeine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Morphine | HCID 5288826 | — |
| Catalyst | Phenyltrimethylammonium chloride | HCID 67309 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Codeine | HCID 5284371 | 99% |
Reaction Steps
Morphine of 70% purity 407 parts (1 mole part), potassium carbonate 552 parts (4 moles part) and trimethylphenyl-ammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene (4000 parts) at 45° to 120° C. for 2-5 hrs. to yield 296 parts codeine (99% yield), after workup as in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764615 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-34708d9017c242a1807b06f30eea7b19 |
| Source note | uspto-grants-1988_08 |