Hexane → [1-(3,5-Dibenzyloxybenzyl)-4-phenyl-3-pyrrolyl]methanol

Participants

Reaction Steps

Lithium aluminium hydride (1.97 g) was added to a solution of methyl 1-(3,5-dibenzyloxybenzyl)-4-phenyl-3-pyrrolecarboxylate (26.2 g) in tetrahydrofuran (250 ml) at 0° C., and the mixture was stirred at room temperature for one hour. Sodium sulfate decahydrate (16.1 g) and hexane (250 ml) were added to the reaction mixture, and the mixture was stirred at room temperature for 30 minutes. After the precipitate was removed by filtration, the filtrate was concentrated. The colorless crystals obtained were collected by filtration to yield [1-(3,5-dibenzyloxybenzyl)-4-phenyl-3-pyrrolyl]methanol (24.20 g, yield: 98%). This was recrystallized from tetrahydrofuran-hexane. Melting point: 115–116° C.

Provenance & Evidence