HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Codeine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Morphine | HCID 5288826 | — |
| Catalyst | Phenyltrimethylammonium chloride | HCID 67309 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Codeine | HCID 5284371 | 97.6% |
Reaction Steps
Morphine of 82.5% purity, 235 parts (1 mole parts), potassium carbonate 276 parts (2 moles part) and trimethylphenyl-ammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene at 45°-110° C. for 4-8 hrs. to yield 292 parts of codeine (97.6% yield) after workup as in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764615 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-816e9d326d0d450a8485433006b3074c |
| Source note | uspto-grants-1988_08 |