Ethanol → HCID 178471112, compound

Participants

Reaction Steps

A mixture of ethyl(E)-3-[1-(4-benzyloxybenzyl)-3-(4-benzyloxybenzyloxy)-1H-pyrazol-4-yl]propenoate (6.61 g), 5% palladium-carbon (13.00 g), ethanol (150 ml), and tetrahydrofuran (150 ml) was stirred for one hour at room temperature under a hydrogen atmosphere. After the palladium-carbon was removed by filtration, the filtrate was concentrated. The crystals obtained were collected by filtration to yield ethyl 3-[1-(4-hydroxybenzyl)-3-hydroxy-1H-pyrazol-4-yl]propionate (2.98 g, yield: 89%). This was recrystallized from ethyl acetate-hexane. Melting point: 143–144° C.

Provenance & Evidence