Sodium sulfate decahydrate → 5-(5-Methyl-2-phenyl-4-oxazolylmethoxy)-3-pyridylmethanol

Participants

Reaction Steps

Lithium aluminium hydride (1.02 g) was added to a solution of methyl 5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-3-pyridinecarboxylate (10.70 g) in tetrahydrofuran (100 ml) at 0° C., which was stirred at room temperature for 30 minutes. Sodium sulfate decahydrate (8.93 g) was added to the reaction mixture, which was stirred at room temperature for 30 minutes. The precipitate was removed by filtration, and the filtrate was concentrated. The resulting colorless crystals were collected by filtration to obtain 5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-3-pyridylmethanol (8.93 g g, yield 91%). This was recrystallized from ethyl acetate-hexane. Melting point: 111–112° C.

Provenance & Evidence