Methanol → HCID 17861351, compound

Participants

Reaction Steps

Sodium borohydride (0.378 g) was added to a mixture of 4-methoxy-3-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde (3.23 g), tetrahydrofuran (15 ml) and methanol (15 ml) at room temperature, which was stirred at room temperature for 30 minutes. The reaction mixture was poured into water, which was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution, dried with anhydrous magnesium sulfate and concentrated to obtain crystals of 4-methoxy-3-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol. This was recrystallized from tetrahydrofuran-hexane to obtain pale yellow plates (3.22 g, 99%). Melting point: 144–145° C.

Provenance & Evidence