Sodium sulfate decahydrate → HCID 17930185, compound

Participants

Reaction Steps

Diisobutylaluminium hydride (1.0M tetrahydrofuran solution, 30 ml) was added to a solution of methyl 2-(5-chloroimidazo[1,2-a]pyridin-2-ylmethoxy)-4-pyridinecarboxylate (3.97 g) in tetrahydrofuran (150 ml) at 0° C., which was stirred at room temperature for 30 minutes. Sodium sulfate decahydrate (12.2 g) was added to the reaction mixture, which was stirred at room temperature for 1 hour. The precipitate was removed by filtration, and the filtrate was concentrated. The resulting colorless crystals were collected by filtration to obtain 2-(5-chloroimidazo[1,2-a]pyridin-2-ylmethoxy)-4-pyridylmethanol (3.12 g, yield 86%). This was recrystallized from tetrahydrofuran-hexane. Melting point: 143–144° C.

Provenance & Evidence