HCID 69423063, compound → HCID 23025043, compound

Participants

Reaction Steps

A mixture of 1-(4-benzyloxybenzyl)-3-(4-fluorophenyl)-1H-pyrazol-4-ylmethanol (11.7 g), active manganese dioxide (20.0 g) and tetrahydrofuran (150 ml) was stirred at room temperature for 2 hours. After the manganese dioxide was removed by filtration, the filtrate was concentrated to obtain 1-(4-benzyloxybenzyl)-3-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde (10.9 g, yield 94%) as colorless crystals. This was recrystallized from ethyl acetate-hexane. Melting point: 97–98° C.

Provenance & Evidence