反应详情

To a solution of 3.02 g (8.1 mmol.) of N-(1-phenyl-3-piperidinopropyl)quinaldinamide in a mixture of 18 ml of ethanol and 8 ml of acetone was added a solution of 0.939 g (8.1 mmol.) of fumaric acid in 20 ml of hot ethanol. The resulting mixture was stirred at room temperature and subsequently under chilling with ice. Precipitated crystals were collected by filtration and washed with acetone. The washed crystals were suspended in 60 ml of n-hexane and the suspension was refluxed for 1.5 hours. The crystals were collected by filtration, washed with n-hexane and dried. Thus, 3.10 g (yield: 78%) of the subject compound was obtained as a white crystalline product.

1. temperaturesubsequently under chilling with ice
2. customPrecipitated crystals
3. filtrationwere collected by filtration
4. washwashed with acetone
5. temperaturethe suspension was refluxed for 1.5 hours
6. filtrationThe crystals were collected by filtration
7. washwashed with n-hexane
8. customdried