Sodium sulfate decahydrate → HCID 69423999, compound

Participants

Reaction Steps

Lithium aluminum hydride (320 mg) was added gradually to a solution of methyl 3-(5-methyl-2-phenyl-4-oxazolylmethoxy)-1-(4-phenoxybenzyl)-1H-pyrazole-4-carboxylate (4.00 g) in tetrahydrofuran (30 ml) at 0° C., which was stirred for 2 hours. Sodium sulfate decahydrate (2.95 g) was added to the reaction mixture, and the precipitate was separated by filtration. The filtrate was concentrated, and the residue was subjected to silica gel column chromatography to obtain [3-(5-methyl-2-phenyl-4-oxazolylmethoxy)-1-(4-phenoxybenzyl)-1H-pyrazol-4-yl]methanol (3.56 g, yield 97%) as colorless crystals. This was recrystallized from ethyl acetate-hexane. Melting point: 103–104° C.

Provenance & Evidence