4-Hydroxybenzaldehyde → 4-(5-Methyl-2-phenyl-4-thiazolylmethoxy)benzaldehyde

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-chloromethyl-5-methyl-2-phenylthiazole (5.40 g), 4-hydroxybenzaldehyde (2.91 g), anhydrous potassium carbonate (4.95 g) and N,N-dimethylformamide (50 ml) was stirred at 80° C. for 3 hours. The reaction mixture was poured into water, the precipitated solid was collected by filtration, and air-dried to obtain crystals of 4-(5-methyl-2-phenyl-4-thiazolylmethoxy)benzaldehyde (6.85 g, yield 93%). This was recrystallized from ethyl acetate-hexane to obtain colorless prisms. Melting point: 118–119° C.

Provenance & Evidence