(3-Amino-3-phenylpropyl)diethylamine → N-(3-diethylamino-1-phenylpropyl)quinaldinamide
Reaction equation
[NH2:1][CH:2]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:3][CH2:4][N:5]([CH2:8][CH3:9])[CH2:6][CH3:7].[N:16]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][C:17]=1[CH2:18][C:19](Cl)=[O:20]>>[CH2:8]([N:5]([CH2:6][CH3:7])[CH2:4][CH2:3][CH:2]([NH:1][C:19]([CH2:18][C:17]1[CH:22]=[CH:23][C:24]2[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:16]=1)=[O:20])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[CH3:9]Participants
3
Procedure
The procedure of Example 1 was repeated using 618 mg (3.0 mmol.) of N-(3-amino-3-phenylpropyl)-N,N-diethylamine and 575 mg (3.0 mmol.) of quinaldinoyl chloride, to obtain 1.08 g (yield: 100%) of the subject compound as a pale yellow oily product.
Sources & evidence
- ORD record
- ord-994c806bbab74cfa828c8d8b2e3961ea
- Source dataset
- uspto-grants-1988_08
- Patent number
- US04764617
Reaction notes
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