Hydrochloric Acid → 4-(5-Methyl-2-phenyl-4-thiazolylmethoxy)benzyl alcohol

Participants

Reaction Steps

Sodium borohydride (0.38 g) was added to a mixture of 4-(5-methyl-2-phenyl-4-thiazolylmethoxy)benzaldehyde (6.00 g), tetrahydrofuran (30 ml) and methanol (20 ml) under ice-cooling, which was stirred at room temperature for 30 minutes. The reaction mixture was neutralized with dilute hydrochloric acid and water to give a precipitate, which was collected by filtration and air-dried to obtain crystals of 4-(5-methyl-2-phenyl-4-thiazolylmethoxy)benzyl alcohol (5.68 g, yield 94%). This was recrystallized from ethyl acetate-hexane to obtain colorless prisms. Melting point: 94–95° C.

Provenance & Evidence